Menu:

Latest news:

Sep 25, 2020:
New paper on biosensor engineering is out in Nat Commun, see HERE

Jun 15, 2020:
IAPP fibril paper is out in NSMB: HERE

Feb 12, 2020:
New preprint on bioRxiv: Amyloid fibril structure of islet amyloid polypeptide by cryo-electron microscopy reveals similarities with amyloid beta

Aug 21, 2019:
New publication in Nature Communications on the PI3K-SH3 amyloid fibril structure by Cryo-EM. see here.

Aug 7, 2019:
New DireX Version 0.7.1. Added a turbo mode, which is much faster (but less accurate). Download here.

Sep 10, 2017:
New publication in Science on the Abeta(1-42) fibril structure. see here.

Sep 1, 2017:
We have new job openings for postdocs and PhD students, see here.

Jul 10, 2017:
Congratulations to Michaela, Amudha, and Tatjana on their successful PhD Defenses!

Dec 4, 2015:
Congratulations to Dennis on his successfull PhD Defense!

Nov 22, 2015:
New publications on our protein structure refinement method and CASP11 results.

Feb 3, 2015:
Congratulations to Zhe on his successfull PhD Defense!

Video Lectures


VISDEM Density Sharpening

The VISDEM method improves the visualization of density maps by using general statistical information about proteins for the sharpening process. In particular, the packing density of atoms is highly similar between different proteins, which allows for building a pseudo-atomic model to approximate the true mass distribution. From this model the radial structure factor and density value histogram are estimated and applied as constraints to the 3D reconstruction in reciprocal- and real-space, respectively.




Real-space model refinement with DireX

This video introduces the real-space refinement program DireX, which has been developed to refine protein structures against low-resolution density maps from Cryo-EM or X-ray crystallography.

Read more about DireX and watch movies of the flexible fitting...



Deformable Elastic Network (DEN)

The concept of Deformable Elastic Network restraints is introduced, which is used to avoid overfitting during low-resolution refinements.