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Aug 21, 2019:
New publication in Nature Communications on the PI3K-SH3 amyloid fibril structure by Cryo-EM. see here.

Aug 7, 2019:
New DireX Version 0.7.1. Added a turbo mode, which is much faster (but less accurate). Download here.

Sep 10, 2017:
New publication in Science on the Abeta(1-42) fibril structure. see here.

Sep 1, 2017:
We have new job openings for postdocs and PhD students, see here.

Jul 10, 2017:
Congratulations to Michaela, Amudha, and Tatjana on their successful PhD Defenses!

Dec 4, 2015:
Congratulations to Dennis on his successfull PhD Defense!

Nov 22, 2015:
New publications on our protein structure refinement method and CASP11 results.

Feb 3, 2015:
Congratulations to Zhe on his successfull PhD Defense!

Structures in the PDB (Protein Data Bank)


(57 structures in total)

6R4R
EMD-4727
Cryo-EM Structure of the PI3-Kinase SH3 Domain Amyloid Fibril Roeder, C., Vettore, N., Mangels, L.N., Gremer, L., Ravelli, R.B.G., Willbold, D., Hoyer, W., Buell, A.K., Schroder, G.F.

6G2T
human cardiac myosin binding protein C C1 Ig-domain bound to native cardiac thin filament
Risi, C., Belknap, B., Forgacs-Lonart, E., Harris, S.P., Schroder, G.F., White, H.D., Galkin, V.E. (2018) Structure 26 1604-1611.e4

6CXI
Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C mode 1
6CXJ
Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C mode 2
N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament. Risi, C., Belknap, B., Forgacs-Lonart, E., Harris, S.P., Schroder, G.F., White, H.D., Galkin, V.E. (2018) Structure 26 1604

5OQV
Near-atomic resolution fibril structure of complete amyloid-beta(1-42) by cryo-EM
Gremer, L., Schoelzel, D., Schenk, C., Reinartz, E., Labahn, J., Ravelli, R.B.G., Tusche, M., Lopez-Iglesias, C., Hoyer, W., Heise, H., Willbold, D., Schroder, G.F. (2017) Science 358 116-119

5NOG
Ca2+-induced Movement of Tropomyosin on Native Cardiac Thin Filaments - "Blocked" state
5NOJ
Ca2+-induced Movement of Tropomyosin on Native Cardiac Thin Filaments - "OPEN" state
5NOL
Ca2+-induced Movement of Tropomyosin on Native Cardiac Thin Filaments - "Closed" state
Ca(2+)-induced movement of tropomyosin on native cardiac thin filaments revealed by cryoelectron microscopy. Risi, C., Eisner, J., Belknap, B., Heeley, D.H., White, H.D., Schroder, G.F., Galkin, V.E. (2017) Proc Natl Acad Sci U S A 114 6782-6787

5KYH
Structure of Iho670 Flagellar-like Filament
Braun, T., Vos, M.R., Kalisman, N., Sherman, N.E., Rachel, R., Wirth, R., Schroder, G.F., Egelman, E.H. (2016) Proc Natl Acad Sci U S A 113 10352-10357

5K5G
Structure of human islet amyloid polypeptide in complex with an engineered binding protein
Mirecka, E.A., Feuerstein, S., Gremer, L., Schroeder, G.F., Stoldt, M., Willbold, D., Hoyer, W. Scientific Reports volume 6, Article number: 33474 (2016)

5KYH
Structure of Iho670 Flagellar-like Filament
Braun, T., Vos, M.R., Kalisman, N., Sherman, N.E., Rachel, R., Wirth, R., Schroder, G.F., Egelman, E.H. (2016) Proc Natl Acad Sci U S A 113 10352-10357

5LZA
Structure of the 70S ribosome with SECIS-mRNA and P-site tRNA (Initial complex, IC)
5LZB
Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the initial binding state (IB)
5LZC
Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the codon reading state (CR)
5LZD
Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the GTPase activated state (GA)
5LZE
Structure of the 70S ribosome with Sec-tRNASec in the classical pre-translocation state (C)
5LZF
Structure of the 70S ribosome with fMetSec-tRNASec in the hybrid pre-translocation state (H)

The pathway to GTPase activation of elongation factor SelB on the ribosome. Fischer, N., Neumann, P., Bock, L.V., Maracci, C., Wang, Z., Paleskava, A., Konevega, A.L., Schroder, G.F., Grubmuller, H., Ficner, R., Rodnina, M.V., Stark, H. (2016) Nature 540: 80-85

3J8I
Near-Atomic Resolution for One State of F-Actin
3J8J
Tilted state of actin, T1
3J8K
Tilted state of actin, T2
Near-Atomic Resolution for One State of F-Actin
Galkin, V.E., Orlova, A., Vos, M.R., Schroder, G.F., Egelman, E.H. (2015) Structure 23 173-182

4CHV
4CHW
The electron crystallography structure of the cAMP-free potassium channel MloK1
Kowal, J., Chami, M., Baumgartner, P., Arheit, M., Chiu, P.L., Rangl, M., Scheuring, S., Schroder, G.F., Nimigean, C.M., Stahlberg, H. (2014) Nat Commun 5 3106-3106

3J63
Unified assembly mechanism of ASC-dependent inflammasomes
Lu, A., Magupalli, V.G., Ruan, J., Yin, Q., Atianand, M.K., Vos, M.R., Schroder, G.F., Fitzgerald, K.A., Wu, H., Egelman, E.H. (2014) Cell 156 1193-1206

4V8R
The crystal structures of the eukaryotic chaperonin CCT reveal its functional partitioning
Kalisman, N., Schroder, G.F., Levitt, M. (2013) Structure 21 540

4B2T
The crystal structures of the eukaryotic chaperonin CCT reveal its functional partitioning
Kalisman, N., Schroeder, G.F., Levitt, M. (2013) Structure 21 540

3ZPZ
3ZQ0
3ZQ1
Visualizing GroEL-ES in the Act of Encapsulating a Non-Native Substrate Protein
Chen, D.H., Madan, D., Weaver, J., Lin, Z., Schroder, G.F., Chiu, W., Rye, H.S. (2013) Cell 153 1354

4V6Y
E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1a)
4V6Z
E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1b)
4V70
E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre3)
4V71
E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre2)
4V72
E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre4)
4V73
E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5a)
4V74
70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5b)
4V75
E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic post-translocation state (post1)
4V76
E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2a)
4V77
E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2b)
4V78
E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post3a)
4V79
E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post3b)
4V7A
E. coli 70S-fMetVal-tRNAVal post-translocation complex (post4)
Bock, L.V., Blau, C., Schroder, G.F., Davydov, I.I., Fischer, N., Stark, H., Rodnina, M.V., Vaiana, A.C., Grubmuller, H. (2013) Nat Struct Mol Biol 20 1390-1396

3J1R
Filaments from Ignicoccus hospitalis Show Diversity of Packing in Proteins Containing N-terminal Type IV Pilin Helices
Yu, X., Goforth, C., Meyer, C., Rachel, R., Wirth, R., Schroder, G.F., Egelman, E.H. (2012) J Mol Biol 422 274-281

4FE1
Improving the Accuracy of Macromolecular Structure Refinement at 7 A Resolution
Brunger, A.T., Adams, P.D., Fromme, P., Fromme, R., Levitt, M., Schroder, G.F. (2012) Structure 20 957-966

4A0O
Symmetry-free cryo-EM map of TRiC in the nucleotide-free (apo) state
Cong, Y., Schroder, G.F., Meyer, A.S., Jakana, J., Ma, B., Dougherty, M.T., Schmid, M.F., Reissmann, S., Levitt, M., Ludtke, S.L., Frydman, J., Chiu, W. (2012) EMBO J 31 720

4A0V
model refined against the Symmetry-free cryo-EM map of TRiC-AMP-PNP
Cong, Y., Schroder, G.F., Meyer, A.S., Jakana, J., Ma, B., Dougherty, M.T., Schmid, M.F., Reissmann, S., Levitt, M., Ludtke, S.L., Frydman, J., Chiu, W. (2012) EMBO J 31 720

4A0W
model built against symmetry-free cryo-EM map of TRiC-ADP-AlFx
Cong, Y., Schroder, G.F., Meyer, A.S., Jakana, J., Ma, B., Dougherty, M.T., Schmid, M.F., Reissmann, S., Levitt, M., Ludtke, S.L., Frydman, J., Chiu, W. (2012) EMBO J 31 720

4A13
model refined against symmetry-free cryo-EM map of TRiC-ADP
Cong, Y., Schroder, G.F., Meyer, A.S., Jakana, J., Ma, B., Dougherty, M.T., Schmid, M.F., Reissmann, S., Levitt, M., Ludtke, S.L., Frydman, J., Chiu, W. (2012) EMBO J 31 720

3TX8
Crystal structure of a succinyl-diaminopimelate desuccinylase (ArgE) from Corynebacterium glutamicum ATCC 13032 at 2.97 A resolution
Brunger, A.T., Das, D., Deacon, A.M., Grant, J., Terwilliger, T.C., Read, R.J., Adams, P.D., Levitt, M., Schroder, G.F. (2012) Acta Crystallogr D Biol Crystallogr 68 391-403

3J0S
Remodeling of actin filaments by ADF cofilin proteins
Galkin, V.E., Orlova, A., Kudryashov, D.S., Solodukhin, A., Reisler, E., Schroder, G.F., Egelman, E.H. (2011) Proc Natl Acad Sci U S A 108 20568-20572


3QJO
Refined Structure of the functional unit (KLH1-H) of keyhole limpet hemocyanin
Jaenicke, E., Buchler, K., Decker, H., Markl, J., Schroder, G.F. (2011) IUBMB Life 63 183-187

2XE6
The complete reaction cycle of human phosphoglycerate kinase: The open binary complex with 3PG
2XE7
The complete reaction cycle of human phosphoglycerate kinase: The open ternary complex with 3PG and ADP
2XE8
The complete reaction cycle of human phosphoglycerate kinase: The open ternary complex with 3PG and AMP-PNP
Zerrad, L., Merli, A., Schroder, G.F., Varga, A.V., Graczer, E., Pernot, P., Round, A., Vas, M., Bowler, M.W. (2011) J Biol Chem 286 14040

3SZR
Crystal structure of modified nucleotide-free human MxA
Gao, S., von der Malsburg, A., Dick, A., Faelber, K., Schroder, G.F., Haller, O., Kochs, G., Daumke, O. (2011) Immunity 35 514-525

3IYF
Atomic Model of the Lidless Mm-cpn in the Open State
Zhang, J., Baker, M.L., Schroder, G.F., Douglas, N.R., Reissmann, S., Jakana, J., Dougherty, M., Fu, C.J., Levitt, M., Ludtke, S.J., Frydman, J., Chiu, W. (2010) Nature 463 379-383

3LOS
Atomic Model of Mm-cpn in the Closed State
Zhang, J., Baker, M.L., Schroder, G.F., Douglas, N.R., Reissmann, S., Jakana, J., Dougherty, M., Fu, C.J., Levitt, M., Ludtke, S.J., Frydman, J., Chiu, W. (2010) Nature 463 379-383

2K39
Recognition dynamics up to microseconds revealed from RDC derived ubiquitin ensemble in solution
Lange, O.F., Lakomek, N.A., Fares, C., Schroder, G.F., Walter, K.F.A., Becker, S., Meiler, J., Grubmuller, H., Griesinger, C., de Groot, B.L. (2008) Science 320 1471-1475