Latest news:

Sep 10, 2017:
New publication in Science on the Abeta(1-42) fibril structure. see here.

Sep 1, 2017:
We have new job openings for postdocs and PhD students, see here.

Jul 10, 2017:
Congratulations to Michaela, Amudha, and Tatjana on their successfull PhD Defenses!

Dec 4, 2015:
Congratulations to Dennis on his successfull PhD Defense!

Nov 22, 2015:
New publications on our protein structure refinement method and CASP11 results.

Feb 3, 2015:
Congratulations to Zhe on his successfull PhD Defense!



50. K. R. Pothula, D. Smyrnova, G. F. Schröder Clustering cryo-EM images of helical protein polymers for helical reconstructions
Ultramicroscopy (2018), accepted.
49. C. Möckel, J. Kubiak, O. Schillinger, R. Kühnemuth, D. Della Corte, G. F. Schröder, D. Willbold, B. Strodel, C. A. M. Seidel, P. Neudecker Integrated NMR, Fluorescence, and Molecular Dynamics Benchmark Study of Protein Mechanics and Hydrodynamics
J. Phys. Chem. B (2018), accepted.
48. C. Risi, B. Belknap, E. Forgacs-Lonart, S. P. Harris, G. F. Schröder, H. D. White, V. E. Galkin N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament
Structure (2018) 26:1-8


47. L. Gremer, D. Schölzel, C. Schenk, E. Reinartz, Jörg Labahn, R.B.G. Ravelli, M. Tusche, C. Lopez- Iglesias, W. Hoyer, H. Heise, D. Willbold, G.F. Schröder. Fibril structure of amyloid-ß(1-42) by cryo-electron microscopy
Science 358:116–119 (2017)
See Science Perspectives article by Popich and Raunser
46. A. Toulmin, L.E. Baltierra-Jasso, M.J. Morten, T. Sabir, P. McGlynn, G.F. Schröder, B.O. Smith, S.W. Magennis. Conformational heterogeneity in a fully-complementary DNA three-way junction with a GC-rich branchpoint
Biochemistry (2017) 56(37):4985-4991
45. C. Risi, J. Eisner, B. Belknap, D. H. Heeley, H. D. White, G. F. Schröder, V. E. Galkin. Ca2+-induced Movement of Tropomyosin on Native Cardiac Thin Filaments Revealed by Cryo Electron Microscopy
PNAS (2017) 114:6782-6787


44. N. Fischer, P. Neumann, L. V. Bock, C. Maracci, Z. Wang, A. Paleskava, A. L. Konevega, G. F. Schröder, H. Grubmüller, R. Ficner, M. V. Rodnina, and H. Stark. The pathway to GTPase activation of elongation factor SelB on the ribosome
Nature (2016), accepted.
43. E.A. Mirecka, S. Feuerstein, L. Gremer, G. F. Schröder, M. Stoldt, D. Willbold, and W. Hoyer. β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor
Sci. Rep. (2016), in press.
42. T. Braun, M. Vos, N. Kalisman, N. E. Sherman, R. Rachel, R. Wirth, G.F. Schröder, and E. Egelman. Archaeal Flagellin Combines a Bacterial Type IV Pilin Domain with an Immunoglobulin-like Domain
PNAS (2016), in press.


41. A. Wildberg, D. Della Corte, and G.F. Schröder. Coupling an ensemble of homologs improves refinement of protein homology models
J. Chem. Theo. Comput. (2015), 11(12):5578-5582
40. D. Della Corte, A. Wildberg, and G.F. Schröder. Protein Structure Refinement with Adaptively Restrained Homologous Replicas
Proteins (2015), doi:10.1002/prot.24939
39. M. Spiegel, A.K. Duraisamy, and G.F. Schröder. Improving the Visualisation of Cryo-EM Density Reconstructions
J.Struct.Biol. (2015), 191(2):207-213
38. T. Braun, A. Orlova, K. Valegård, A.-C. Lindås, G.F. Schröder, and E. H. Egelman. An Archaeal Actin from a Hyperthermophile Forms a Single-Stranded Filament
PNAS (2015), 112(30): 9340-9345.
37. A. Sali, H. M. Berman, T. Schwede, J. Trewhella, G. Kleywegt, S. K. Burley, J. Markley, H. Nakamura, P. Adams, A.M.J.J. Bonvin, W. Chiu, M. Dal Peraro, F. DiMaio, T. E. Ferrin, Kay Grünewald, A. Gutmanas, R. Henderson, G. Hummer, K. Iwasaki, G. Johnson, C. L. Lawson, J. Meiler, M. A. Marti-Renom, G. T. Montelione, M. Nilges, R. Nussinov, A. Patwardhan, J. Rappsilber, R. J. Read, H. Saibil, G.F. Schröder, C. Schwieters, C. A. M. Seidel, D. Svergun, M. Topf, E. L. Ulrich, S. Velankar, and J. D. Westbrook. Outcome of the First wwPDB Hybrid / Integrative Methods Task Force Workshop
Structure (2015) 23(7): 1156-1167.
36. G.F. Schröder. Hybrid Methods for Macromolecular Structure Determination: Experiment with Expectations
Curr. Opin. Struct. Biol. (2015) 31: 20-27. Click here to download
35. V.E. Galkin, A. Orlova, M.R. Vos, G.F. Schröder, and E.H. Egelman. Near-Atomic Resolution for One State of F-Actin
Structure (2015) 23(1): 173-182


34. G.F. Schröder, M.L. Levitt, and A.T. Brunger Deformable elastic network refinement for low-resolution macromolecular crystallography
Acta Cryst. D (2014) D70: 2241–2255
33. A. Lu, V.G. Magupalli, J. Ruan, Q. Yin, M.K. Atianand, M. Vos, G.F. Schröder, K.A. Fitzgerald, H. Wu, and E.H. Egelman Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
Cell (2014) 156(6): 1193–1206
32. J. Kowal, M. Chami, P. Baumgartner, M. Arheit, P.-L. Chiu, M. Rangl, S. Scheuring, G.F. Schröder, C.M. Nimigean, H. Stahlberg. Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1
Nature Communications (2014) 5, 3106.


31. L.V. Bock, C. Blau, G.F. Schröder, I.I. Davydov, N. Fischer, H. Stark, M.V. Rodnina, A.C. Vaiana, and H. Grubmüller. Energy barriers and driving forces in tRNA translocation through the ribosome
Nat Struct Mol Biol (2013) 20:1390–1396
30. B. Falkner and G.F. Schröder. Cross-validation in cryo-electron microscopy based structural modeling
PNAS (2013) 110(22):8930-8935. [PDF]
29. D.-H. Chen, D. Madan, J. Weaver, Z. Lin, G.F. Schröder, W. Chiu, H.S. Rye. Visualizing GroEL/ES in the Act of Encapsulating a Folding Protein
Cell (2013) 153:1354–1365. [PDF]
28. N. Kalisman, G.F. Schröder, M. Levitt. The Crystal Structures of the Eukaryotic Chaperonin CCT Reveal its Functional Partitioning
Structure (2013) 21:540–549. [PDF]
27. X. Deng, J. Morris, C. Chaton, G.F. Schröder, W.S. Davidson and T.B. Thompson. Small-angle X-ray Scattering of Apolipoprotein A-IV Reveals the Importance of Its Termini for Structural Stability
J. Biol. Chem. (2013) 288(7):4854-4866. [PDF]


26. X. Yu, C. Goforth, C. Meyer, R. Rachel, R. Wirth, G.F. Schröder, and E.H. Egelman. Filaments from Ignicoccus hospitalis Show Diversity of Packing in Proteins Containing N-terminal Type IV Pilin Helices.
J. Mol. Biol. (2012) 422(2): 274-281. [PDF]
25. A.T. Brunger, P.D. Adams, P. Fromme, R. Fromme, M. Levitt, and G.F. Schröder. Improving the accuracy of macromolecular structure refinement at 7 Å resolution.
Structure (2012), 20(6):957-966. [PDF]
24. T. Sabir, A. Toulmin, L. Ma, A.C. Jones, P. McGlynn, G.F. Schröder, and S.W. Magennis. Branchpoint expansion in a fully-complementary three-way DNA junction.
J. Am. Chem. Soc. (2012), 134(14):6280–6285. [PDF] ( See Cover)
23. Z. Wang, G.F. Schröder. Real-space Refinement with DireX: From Global Fitting to Side-chain Improvements.
Biopolymers (2012), 97(9):687-697. [PDF]
22. R. Henderson, A. Sali, M.L. Baker, B. Carragher, B. Devkota, K.H. Downing, E.H. Egelman, Z. Feng, J. Frank, N. Grigorieff, W. Jiang, S.J. Ludtke, O. Medalia, P.A. Penczek, P.B. Rosenthal, M.G. Rossmann, M.F. Schmid, G.F. Schröder, A.C. Steven, D.L. Stokes, J.D. Westbrook, W. Wriggers, H. Yang, J. Young, H.M. Berman, W. Chiu, G.J. Kleywegt, C.L. Lawson. Outcome of the First Electron Microscopy Validation Task Force Meeting.
Structure (2012) 20:205-214. [PDF]
21. D.J. O'Donovan, I. Stokes-Rees, Y. Nam, S. Blacklow, G.F. Schröder, A.T. Brunger, Piotr Sliz. A grid-enabled web service for low-resolution crystal structure refinement.
Acta Cryst. (2012) D68:268-276. [PDF]
20. A.T. Brunger, D. Das, A.M. Deacon, J. Grant, T.C. Terwilliger, R.J. Read, P.D. Adams, M. Levitt and G.F. Schröder. Application of DEN-Refinement And Automated Model-Building To A Difficult Case Of Molecular Replacement Phasing: The Structure Of A Putative Succinyl-Diaminopimelate Desuccinylase From Corynebacterium Glutamicum.
Acta Cryst. (2012). D68, 391-403 [PDF]


19. V.E. Galkin, A. Orlova, D. Kudryashov, A. Solodukhin, E. Reisler, G.F. Schröder, and E.H. Egelman. Remodeling of Actin Filaments by ADF/Cofilin Proteins.
PNAS (2011) 108(51):20568-20572 . [PDF]
18. S. Gao, A. von der Malsburg, A. Dick, K. Faelber, G.F. Schröder, O. Haller, G. Kochs, O. Daumke. Three domain architecture of dynamin-like MxA GTPase.
Immunity (2011) 35:514-525. [PDF]
17. Y. Cong, G.F. Schröder, A.S. Meyer, J. Jakana, B. Ma, M.T. Dougherty, M.F. Schmid, S. Reissmann, M. Levitt, S.L. Ludtke, J. Frydman, and W. Chiu. Symmetry-Free Cryo-EM Structures of the Chaperonin TRiC Along its ATPase-Driven Conformational Cycle.
EMBO J (2011) 31:720-730. [PDF]
16. E. Jaenicke, K. Büchler, H. Decker, J. Markl, T. Barends, and G.F. Schröder. The Refined Structure of Functional Unit h of Keyhole Limpet Hemocyanin (KLH1-h) Reveals Disulfide Bridges.
IUBMB Life (2011) 63(3):183-187. [PDF]
15. L. Zerrad, A. Merli, G.F. Schröder, A. Varga, E. Gráczer, P. Pernot, A. Round, M. Vas, and M.W. Bowler. A Spring Loaded Release Mechanism Regulates Domain Movement and Catalysis in Phosphoglycerate Kinase.
JBC (2011) 286:14040-14048. [PDF]
14. T. Sabir, G.F. Schröder, A. Toulmin, P. McGlynn, and S.W. Magennis. Global Structure of Forked DNA in Solution Revealed by High-Resolution Single-Molecule Fluorescence Resonance Energy Transfer.
J. Am. Chem. Soc. (2011) 133(5):1188-1191. [PDF]


13. V.E. Galkin, A. Orlova, G.F. Schröder, E.H. Egelman. Structural Polymorphism in F-actin.
Nat Struct Mol Biol (2010) 17:1318-1323. [PDF]
12. G.F. Schröder, M. Levitt, A.T. Brunger. Super-resolution biomolecular crystallography with low-resolution data.
Nature (2010) 464:1218-1222. [PDF]
See also "Preview" by Randy J. Read "From Poor Resolution to Rich Insight" Structure (2010) 18:664-665.
11. J. Zhang, M.L. Baker, G.F. Schröder, N.R. Douglas, S. Reissmann, J. Jakana, M. Dougherty, C.J. Fu, M. Levitt, S.J. Ludtke, J. Frydman, and W. Chiu. Mechanism of folding chamber closure in a group II chaperonin.
Nature (2010) 463:379-383. [PDF]

2001 - 2009

10. A. K. Wozniak, G.F. Schröder, H. Grubmüller, C.A.M. Seidel, F. Oesterhelt. Single molecule FRET measures bends and kinks in DNA.
PNAS (2008) 105(47):18337-18342. [PDF]
9. O.F. Lange, N.-A. Lakomek, C. Fares, G.F. Schröder, S. Becker, J. Meiler, H. Grubmüller, C. Griesinger, B.L. de Groot. Atomistic residual dipolar coupling ensemble of ubiquitin reveals molecular recognition dynamics up to the microsecond timescale.
Science (2008) 320:1471-1475. [PDF]
8. G.F. Schröder, A.T. Brunger, and M. Levitt. Combining Efficient Conformational Sampling with a Deformable Elastic Network Model Facilitates Structure Refinement at Low Resolution.
Structure (2007) 15:1630-1641. [PDF]
7. G. F. Schröder, U. Alexiev, and H. Grubmüller. Simulation of fluorescence anisotropy experiments Probing protein flexibility.
Biophys. J. (2005) 89:3757-3770. [PDF]
6. A. Wozniak, S. Nottrott, E. Kühn-Hölsken, G. F. Schröder, H. Grubmüller, R. Lührmann, A. M. Seidel and F. Oesterhelt. Detecting protein-induced folding of the U4 snRNA kinkturn by single-molecule multiparameter FRET measurements.
RNA (2005) 11:1545-1554. [PDF]
5. G.F. Schröder; Simulation of Fluorescence Spectroscopy Experiments , PhD Thesis, Universität Göttingen, 2004. [PDF]
4. M. Margittai, J. Widengren, E. Schweinberger, G.F. Schröder, S. Felekyan, E. Haustein, M. König, D. Fasshauer, H. Grubmüller, R. Jahn, and C. A. M. Seidel. Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of Syntaxin 1.
PNAS (2003) 100(26):15516-15521. [PDF]
3. G.F. Schröder and H. Grubmüller. Maximum likelihood trajectories from single molecule fluorescence resonance energy transfer experiments.
J. Chem. Phys. (2003) 119(18):9920-9924. [PDF]
2. G.F. Schröder and H. Grubmüller. FRETsg : Biomolecular structure model building from multiple FRET experiments.
Comp. Phys. Comm. (2003) 158:150-157. [PDF]
1. G.F. Schröder Molekulardynamiksimulation der Flexibilität und Fluoreszenzanisotropie eines an ein Protein gebundenen Farbstoffs, Diploma Thesis, Universität Göttingen, 2001. [PDF]