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Molecular Structure and Biophysics Group Head: Gunnar F. Schröder Ernst-Ruska-Centre (ER-C-3) Forschungszentrum Jülich and Professor of Molecular Biophysics at Heinrich-Heine University Düsseldorf |
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| The group studies the molecular basis of amyloid-related diseases, including Alzheimer's, Parkinsons's, and diabetes. Using cryo-electron microscopy (cryo-EM), we determine the structures of amyloid proteins to gain insights into their aggregation and pathological roles. Furthermore, the group develops computational methods for modeling and refinement of protein structures from low-resolution data and explores applications in protein and peptide design. |
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| We are working on the prediction of local structural details using molecular dynamics simulation techniques to improve low-resolution model building and homology modeling. The goal is to reliably describe the structure and conformational dynamics of proteins from low or intermediate resolution data. | |
News
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New publication:
Check out our new paper in Methods in Enzymology: Cryo-EM structure determination of amyloid fibrils: Methodology, insights, and practical tools Download the paper here. |